P01.36. Assessment of commercial formulations of mucuna pruriens seeds for Levodopa (L-DOPA) content
نویسندگان
چکیده
Purpose Mucuna pruriens (mucuna) seeds contain 3-6% LDOPA, and have been used in traditional Ayurvedic medicine to treat diseases resembling Parkinson’s disease (PD). Pilot studies in PD show that mucuna seed powder has similar effects to conventional levodopa/carbidopa medication. Formulations of mucuna seed are readily available through the internet, and are used by some PD patients as an alternative to conventional levadopa/carbidopa medication. The purpose of this study was to examine the L-DOPA content of a range of popular mucuna products in order to assess the veracity of label claims.
منابع مشابه
Quantitative Determination of L-DOPA in Seeds of Mucuna Pruriens Germplasm by High Performance Thin Layer Chromatography
Mucuna pruriens Linn. is an important medicinal plant used for treatment of Parkinson's disease and many others in ancient Indian medical system. L-DOPA extracted from seeds of Mucuna is a constituent of more than 200 indigenous drug formulations and is more effective as drug than the synthetic counterpart. A densitometric high performance thin-layer chromatographic (HPTLC) method was developed...
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Mucuna pruriens (Fabaceae), also known as cowitch and velvet bean contains very powerful neurotransmitter precursor L-Dopa. The seeds of Mucuna pruriens accumulate 0.2%-2% L-Dopa in their dry weight. L-Dopa is an amino acid that converts into dopamine. Dopamine is an essential component of our body and it requires for the proper functioning of the brain. The seeds powder of Mucuna pruriens has ...
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Mucuna pruriens is the best known natural source of L-dopa, the gold standard for treatment of Parkinsonism. M. pruriens varieties are protein rich supplements, and are used as food and fodder worldwide. Here, we report L-dopa contents in seeds of fifty six accessions of four M. pruriens varieties, M. pruriens var. pruriens, M. pruriens var. hirsuta, M. pruriens var. utilis and M. pruriens var....
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L-Dopa is the drug of choice in the treatment of Parkinson's disease but it has dose related adverse effects such as nausea, vomiting, orthostatic hypotension, end of dose deterioration, on off phenomena and on chronic therapy motor complications synonymous to parkinsonism. Mucuna pruriens (M.P) commonly known as velvet beans or cowitch are used in case of spasms associated with Parkins onism. ...
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Velvet bean (Mucuna pruriens) seeds contain the catecholic amino acid L-DoPA (L-3,4-dihydroxyphenylalanine), which is a neurotransmitter precursor and used for the treatment of Parkinson's disease and mental disorders. The great demand for L-DoPA is largely met by the pharmaceutical industry through extraction of the compound from wild populations of this plant; commercial exploitation of ...
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